It is known that Tadalafil increases a hypotensive action of nitrates. It occurs as a result of the additive action of nitrates and Tadalafil to metabolism of nitrogen oxide and cyclic guanosine monophosphate. That is why the use of Cialis drug is contraindicated in the setting of the use of nitrates. The results of the clinical tests proved that the non-observance of recommendations and use of Cialis in the setting of the nitrate usage may cause a severe form of hypotension and lethal outcome in separate cases.
Studying the efficiency of Cialis during the prolonged use the scientists conducted several controlled clinical studies. Not only men but also their sexual partners had to tell about the results of the use of Cialis. The latest data indicate that the men who took Tadalafil in the dose of 10 mg once per day for a long time and their partners report about the significantly bigger satisfaction from the sexual intercourse in comparison with a single use of the tabs.
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According to the results of the studies Cialis does not show the clinically significant effect with the main classes of the antihypertensive remedies including blocking agents of the calcium channels (amlodipine), beta adrenergic blocking agent (metoprolol), alpha-blockers, thiazide diuretic (bendrofluazide), and Angiotensin II Receptor Blocker which are used in different doses as a monotherapy or in combinations.
A percent of the successful vaginal penetrations after the therapy by Cialis within 12 weeks, in men with different types of the erectile dysfunction was 93%. There were most men with the vascular diseases and pancreatic diabetes among them.
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Studying the clinical pharmacology in 18 healthy volunteers who took Cialis in the single dose there was no arterial hypotension at the simultaneous introduction of Tamsulosin adrenoreceptor blocking agent.
Cialis has the moderately expressed vasodilating and hypotensive properties, and therefore it should not be prescribed in case of the expressed arterial and orthostatic hypotension.
If Cialis is rather effective during the vascular erectile dysfunction, the results of the use of Cialis are worse in case of the presence of the pathological venous drainage. The effect appears seldom and not during every use of the tablets.
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Tadalafil did not provide the clinically significant effect to the pharmacokinetics of theophylline. Taking Tadalafil patients who got theophylline experienced a slight increase (3 beats per minute) of the heart contractions conditioned by theophylline.